Microplastics could be a factor in driving up cases of osteoporosis worldwide, according to recently published research. The study reveals that when these tiny plastic particles enter the body, they disrupt the functioning of bone marrow stem cells, which are essential for maintaining and repairing bone tissue.
Throughout your life, your bones are replenished. Osteoporosis is a condition where this process goes wrong, with the breakdown of bone outstripping the rate at which it is replaced. This leads to bones weakening over time and becoming more likely to fracture. The condition has many risk factors—age, sex, medications, diet, smoking and drinking, and genetics are all known to influence it—with the disease developing slowly over time. Often people don’t realize they have the condition until they break a bone.
This new analysis, published in the journal Osteoporosis International, adds exposure to microplastics as a potential new risk factor. The research reviewed 62 scientific articles that had run various laboratory and animal tests on the possible effects of micro- and nanoplastics on bone. Analysis of lab experiments showed that microplastics stimulate the formation of osteoclasts, cells created by stem cells in the bone marrow that degrade bone tissue to promote resorption, the process in which the body breaks down and eliminates old or damaged bone.
The study also found that, in relation to bones, plastic particles can reduce the viability of cells, induce premature cellular aging, modify gene expression, and trigger inflammatory responses. The combination of these effects generates an imbalance in which osteoclasts destroy more bone tissue than is regenerated, causing an accelerated weakening of bone structure.
When then looking at animal studies, the researchers found that the accumulation of microplastics in the body decreases the white blood cell count—which is suggestive of alterations in bone marrow function. In addition, these animal studies suggested that the impact of microplastics on osteoclasts may be associated with deterioration of bone microstructure and the formation of irregular structures of cells, increasing the risk of bone fragility, deformities, and fractures.
“In this study, the adverse effects observed culminated, worryingly, in the interruption of the animals’ skeletal growth,” said coauthor Rodrigo Bueno de Oliveira in a press release. “The potential impact of microplastics on bones is the subject of scientific studies and isn’t negligible.”
